The potassium channel from Streptomyces lividans is an integral membrane protein with
sequence similarity to all known K + channels, particularly in the pore region. X-ray analysis …

The gene product of the ob locus is important in the regulation of body weight. The ob product
was shown to be present as a 16-kilodalton protein in mouse and human plasma but was …

Analytical chemists and biochemists have long sought accurate, sensitive methods for
determining the molecu-lar masses of biopolymers such as proteins and carbohydrates. Tradi-…

Voltage-dependent K + channels are members of the family of voltage-dependent cation (K
+ , Na + and Ca 2+ ) channels that open and allow ion conduction in response to changes in …

The ClC chloride channels catalyse the selective flow of Cl - ions across cell membranes,
thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across …

An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic
exchange requires a comprehensive inventory of the molecular components of the NPC and a …

Ion channels exhibit two essential biophysical properties; that is, selective ion conduction,
and the ability to gate-open in response to an appropriate stimulus. Two general categories of …

Lysine methylation of histones is recognized as an important component of an epigenetic
indexing system demarcating transcriptionally active and inactive chromatin domains. …

Living cells regulate the activity of their ion channels through a process known as gating. To
open the pore, protein conformational changes must occur within a channel's membrane-…

Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests
that vaccines that elicit such antibodies would be protective. Thus far, however, few broadly …