Caspases are a critical class of proteases involved in regulating programmed cell death and
other biological processes. Selective inhibitors of individual caspases, however, are lacking…

Targeted protein degradation has emerged as a useful approach for both basic biological
investigations and therapeutic development. However, it can provide confounding results if not …

Deciphering the functional and therapeutic relevance of missense variants—mutations that
change a single amino acid to an alternative residue—is a central challenge in modern …

… Brianna Hill-Payne, Sebastian Dilones, and George Burslem … Brianna Hill-Payne Department
of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, …

… We thank all the rotation students, Brianna Hill-Payne, Reyna Garcia, and Ivanna Molina
for their contributions to the lab set up and discussions. We thank Dr. Igor Brodsky for careful …