Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis
BD Needham, MS Trent - Nature Reviews Microbiology, 2013 - nature.com
Gram-negative bacteria decorate their outermost surface structure, lipopolysaccharide, with
elaborate chemical moieties, which effectively disguises them from immune surveillance and …
elaborate chemical moieties, which effectively disguises them from immune surveillance and …
Gut microbial molecules in behavioural and neurodegenerative conditions
BD Needham, R Kaddurah-Daouk… - Nature Reviews …, 2020 - nature.com
Mounting evidence suggests that the gut microbiome impacts brain development and function.
Gut–brain connections may be mediated by an assortment of microbial molecules that are …
Gut–brain connections may be mediated by an assortment of microbial molecules that are …
Modulating the innate immune response by combinatorial engineering of endotoxin
BD Needham, SM Carroll, DK Giles… - Proceedings of the …, 2013 - National Acad Sciences
Despite its highly inflammatory nature, LPS is a molecule with remarkable therapeutic
potential. Lipid A is a glycolipid that serves as the hydrophobic anchor of LPS and constitutes a …
potential. Lipid A is a glycolipid that serves as the hydrophobic anchor of LPS and constitutes a …
[HTML][HTML] Plasma and fecal metabolite profiles in autism spectrum disorder
BD Needham, MD Adame, G Serena, DR Rose… - Biological …, 2021 - Elsevier
Background Autism spectrum disorder (ASD) is a neurodevelopmental condition with
hallmark behavioral manifestations including impaired social communication and restricted …
hallmark behavioral manifestations including impaired social communication and restricted …
A gut-derived metabolite alters brain activity and anxiety behaviour in mice
Integration of sensory and molecular inputs from the environment shapes animal behaviour.
A major site of exposure to environmental molecules is the gastrointestinal tract, in which …
A major site of exposure to environmental molecules is the gastrointestinal tract, in which …
[HTML][HTML] Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles
…, S Martin-Brevet, K Berding, BD Needham… - Nature …, 2023 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut–brain …
heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut–brain …
Microbiota regulate social behaviour via stress response neurons in the brain
…, TT Lai, G Sharon, CE Schretter, BD Needham… - Nature, 2021 - nature.com
Social interactions among animals mediate essential behaviours, including mating, nurturing,
and defence 1 , 2 . The gut microbiota contribute to social activity in mice 3 , 4 , but the gut–…
and defence 1 , 2 . The gut microbiota contribute to social activity in mice 3 , 4 , but the gut–…
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
…, MS Ladinsky, GG Shastri, T Thron, BD Needham… - elife, 2020 - elifesciences.org
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. …
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. …
[HTML][HTML] Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial
A Stewart Campbell, BD Needham, CR Meyer, J Tan… - Nature medicine, 2022 - nature.com
Autism spectrum disorder (ASD) is defined by hallmark behaviors involving reduced
communication and social interaction as well as repetitive activities and restricted interests. ASD …
communication and social interaction as well as repetitive activities and restricted interests. ASD …
Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder
Social impairment is one of the major symptoms in multiple psychiatric disorders, including
autism spectrum disorder (ASD). Accumulated studies indicate a crucial role for the gut …
autism spectrum disorder (ASD). Accumulated studies indicate a crucial role for the gut …