Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis

BD Needham, MS Trent - Nature Reviews Microbiology, 2013 - nature.com
Gram-negative bacteria decorate their outermost surface structure, lipopolysaccharide, with
elaborate chemical moieties, which effectively disguises them from immune surveillance and …

Gut microbial molecules in behavioural and neurodegenerative conditions

BD Needham, R Kaddurah-Daouk… - Nature Reviews …, 2020 - nature.com
Mounting evidence suggests that the gut microbiome impacts brain development and function.
Gut–brain connections may be mediated by an assortment of microbial molecules that are …

Modulating the innate immune response by combinatorial engineering of endotoxin

BD Needham, SM Carroll, DK Giles… - Proceedings of the …, 2013 - National Acad Sciences
Despite its highly inflammatory nature, LPS is a molecule with remarkable therapeutic
potential. Lipid A is a glycolipid that serves as the hydrophobic anchor of LPS and constitutes a …

[HTML][HTML] Plasma and fecal metabolite profiles in autism spectrum disorder

BD Needham, MD Adame, G Serena, DR Rose… - Biological …, 2021 - Elsevier
Background Autism spectrum disorder (ASD) is a neurodevelopmental condition with
hallmark behavioral manifestations including impaired social communication and restricted …

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

BD Needham, M Funabashi, MD Adame, Z Wang… - Nature, 2022 - nature.com
Integration of sensory and molecular inputs from the environment shapes animal behaviour.
A major site of exposure to environmental molecules is the gastrointestinal tract, in which …

[HTML][HTML] Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles

…, S Martin-Brevet, K Berding, BD Needham… - Nature …, 2023 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut–brain …

Microbiota regulate social behaviour via stress response neurons in the brain

…, TT Lai, G Sharon, CE Schretter, BD Needham… - Nature, 2021 - nature.com
Social interactions among animals mediate essential behaviours, including mating, nurturing,
and defence 1 , 2 . The gut microbiota contribute to social activity in mice 3 , 4 , but the gut–…

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

…, MS Ladinsky, GG Shastri, T Thron, BD Needham… - elife, 2020 - elifesciences.org
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. …

[HTML][HTML] Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial

A Stewart Campbell, BD Needham, CR Meyer, J Tan… - Nature medicine, 2022 - nature.com
Autism spectrum disorder (ASD) is defined by hallmark behaviors involving reduced
communication and social interaction as well as repetitive activities and restricted interests. ASD …

Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder

BD Needham, W Tang, WL Wu - Developmental neurobiology, 2018 - Wiley Online Library
Social impairment is one of the major symptoms in multiple psychiatric disorders, including
autism spectrum disorder (ASD). Accumulated studies indicate a crucial role for the gut …