Bloodborne infections with Candida albicans are an increasingly recognized complication of
modern medicine. Here, we present a mouse model of low-grade candidemia to determine …

Polymicrobial infections often include both fungi and bacteria and can complicate patient
treatment and resolution of infection. Cross-kingdom interactions among bacteria, fungi, and/or …

Candida albicans dimorphism is a crucial virulence factor during invasive candidiasis infections,
which claim the lives of nearly one-half of those afflicted. It has long been believed that …

Low-density granulocytes (LDGs) have been characterized as important immune cells
during healthy and disease states in humans, including microbial infections, cancer, and …

Candida albicans is a ubiquitous mucosal commensal that is normally prevented from causing
acute or chronic invasive disease. Neutrophils contribute to protection in oral infection but …

Neonates are at increased risk for bacterial sepsis. We established that the immune-suppressive
cytokine interleukin-27 (IL-27) is elevated in neonatal mice. Similarly, human cord blood…

Background The increasing magnitude of the opioid crisis and rising rates of neonatal
abstinence syndrome (NAS) diagnoses highlight the need for increased research into how …

The host innate immune system has developed elegant processes for the detection and
clearance of invasive fungal pathogens. These strategies may also aid in the spread of …

Low-density granulocytes (LDGs) are found abundantly in neonatal blood; however, there is
limited mechanistic understanding of LDG interactions with bacteria and innate immune …

Microbial infections early in life remain a major cause of infant mortality worldwide. This is
consistent with immune deficiencies in this population. Interleukin ( IL )‐27 is suppressive …