Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system
…, MM Thompson, BK Matlock, K Weller… - Brain, behavior, and …, 2014 - Elsevier
Obesity is associated with chronic low-grade inflammation in peripheral tissues caused, in
part, by the recruitment of inflammatory monocytes into adipose tissue. Studies in rodent …
part, by the recruitment of inflammatory monocytes into adipose tissue. Studies in rodent …
Methotrexate inhibits NF‐κB activity via long intergenic (noncoding) RNA–p21 induction
CF Spurlock III, JT Tossberg, BK Matlock… - Arthritis & …, 2014 - Wiley Online Library
Objective To determine interrelationships between the expression of long intergenic (noncoding)
RNA–p21 (lincRNA‐p21), NF‐κB activity, and responses to methotrexate (MTX) in …
RNA–p21 (lincRNA‐p21), NF‐κB activity, and responses to methotrexate (MTX) in …
A single-cell atlas of mouse lung development
…, M Ransom, CJ Taylor, D Nichols, BK Matlock… - …, 2021 - journals.biologists.com
Lung organogenesis requires precise timing and coordination to effect spatial organization
and function of the parenchymal cells. To provide a systematic broad-based view of the …
and function of the parenchymal cells. To provide a systematic broad-based view of the …
Combinatorial transcriptional profiling of mouse and human enteric neurons identifies shared and disparate subtypes in situ
…, M Adam, AJ Simmons, JR Monaghan, BK Matlock… - Gastroenterology, 2021 - Elsevier
Background & Aims The enteric nervous system (ENS) coordinates essential intestinal
functions through the concerted action of diverse enteric neurons (ENs). However, integrated …
functions through the concerted action of diverse enteric neurons (ENs). However, integrated …
Multiparameter analysis of stimulated human peripheral blood mononuclear cells: A comparison of mass and fluorescence cytometry
…, AR Greenplate, DK Flaherty, BK Matlock… - Cytometry Part …, 2016 - Wiley Online Library
Mass and fluorescence cytometry are quantitative single cell flow cytometry approaches that
are powerful tools for characterizing diverse tissues and cellular systems. Here mass …
are powerful tools for characterizing diverse tissues and cellular systems. Here mass …
WDR5 is a conserved regulator of protein synthesis gene expression
…, ER Aho, EJ Rellinger, BK Matlock… - Nucleic acids …, 2020 - academic.oup.com
WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in
the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in …
the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in …
[HTML][HTML] Cell-type-specific and disease-associated expression quantitative trait loci in the human lung
…, R Kendle, M Chung, DK Flaherty, BK Matlock… - Nature Genetics, 2024 - nature.com
Common genetic variants confer substantial risk for chronic lung diseases, including
pulmonary fibrosis. Defining the genetic control of gene expression in a cell-type-specific and …
pulmonary fibrosis. Defining the genetic control of gene expression in a cell-type-specific and …
[HTML][HTML] WIN site inhibition disrupts a subset of WDR5 function
…, AC Florian, LR Thomas, JH Creighton, BK Matlock… - Scientific Reports, 2022 - nature.com
WDR5 nucleates the assembly of histone-modifying complexes and acts outside this
context in a range of chromatin-centric processes. WDR5 is also a prominent target for …
context in a range of chromatin-centric processes. WDR5 is also a prominent target for …
Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler
…, K Guerrazzi, TS McCann, TM Popay, BK Matlock… - Oncogene, 2021 - nature.com
The SNF5 subunit of the SWI/SNF chromatin remodeling complex has been shown to act as
a tumor suppressor through multiple mechanisms, including impairing the ability of the …
a tumor suppressor through multiple mechanisms, including impairing the ability of the …
[HTML][HTML] Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation
…, JL Kuck, AC Shaver, DK Flaherty, BK Matlock… - Communications …, 2022 - nature.com
Cellular metabolism influences immune cell function, with mitochondrial fatty acid β-oxidation
and oxidative phosphorylation required for multiple immune cell phenotypes. Carnitine …
and oxidative phosphorylation required for multiple immune cell phenotypes. Carnitine …