Neutrophils are innate immune effector cells that traffic from the circulation to extravascular
sites of inflammation. β2 integrins are important mediators of the processes involved in …

The development and use of murine myeloid progenitor cell lines that are conditionally
immortalized through expression of HoxB8 has provided a valuable tool for studies of neutrophil …

Sepsis remains an important health problem worldwide due to inefficient treatments often
resulting in multi-organ failure. Neutrophil recruitment is critical during sepsis. While …

PTEN, a tumor suppressor protein that dephosphorylates phosphoinositides at the 3-position
of the inositol ring, is a cytosolic protein that needs to associate with the plasma membrane …

Neutrophils are rapidly mobilized from the circulation to sites of inflammation. The
mechanisms of neutrophil trafficking in the lung are distinct from those in the periphery, in part …

A broad range of cellular functions have been linked to dynamically controlled phosphoinositide
gradients, including the migration of Dictyostelium discoideum and human neutrophils. …

An international consensus report in 2019 recommended a classification system for limbic-predominant
age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The …

This work describes a method that utilizes a microfluidic gradient generator to develop lateral
lipid gradients in supported lipid bilayers (SLB). The new methodology provides freedom of …

Neutrophils are vital for host defense, but dysregulation in the pulmonary microvessels can
cause acute lung injury and lead to acute respiratory distress syndrome. Understanding …

Context The current upsurge in telehealth use in palliative and hospice care warrants
consideration of patient, family caregiver, and interdisciplinary palliative perspectives on telehealth …