[HTML][HTML] Long-primed germinal centres with enduring affinity maturation and clonal migration
…, A Kaur, C Allers, M Fahlberg, BF Grasperge… - Nature, 2022 - nature.com
Germinal centres are the engines of antibody evolution. Here, using human immunodeficiency
virus (HIV) Env protein immunogen priming in rhesus monkeys followed by a long period …
virus (HIV) Env protein immunogen priming in rhesus monkeys followed by a long period …
[HTML][HTML] Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
…, M Robbiani, E Martinelli, B Grasperge… - Nature …, 2018 - nature.com
Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven
in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and …
in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and …
[HTML][HTML] A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy
…, M Aravantinou, N Derby, B Grasperge… - Journal of Controlled …, 2015 - Elsevier
Women urgently need a self-initiated, multipurpose prevention technology (MPT) that
simultaneously reduces their risk of acquiring HIV-1, HSV-2, and HPV (latter two associated with …
simultaneously reduces their risk of acquiring HIV-1, HSV-2, and HPV (latter two associated with …
Evaluation of the host immune response to decellularized lung scaffolds derived from α-Gal knockout pigs in a non-human primate model
…, H Hara, W Lee, CB Trygg, PJ Didier, BF Grasperge… - Biomaterials, 2018 - Elsevier
Whole organ tissue engineering is a promising approach to address organ shortages in many
applications, including lung transplantation for patients with chronic pulmonary disease. …
applications, including lung transplantation for patients with chronic pulmonary disease. …
A subcutaneous implant of tenofovir alafenamide fumarate causes local inflammation and tissue necrosis in rabbits and macaques
…, MM Peet, D Karunakaran, B Grasperge… - Antimicrobial agents …, 2020 - Am Soc Microbiol
We describe the in vitro and in vivo evaluation of a subcutaneous reservoir implant delivering
tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-…
tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-…
[HTML][HTML] A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates
…, A Kaur, C Allers, M Fahlberg, BF Grasperge… - Nature …, 2023 - nature.com
Adjuvants and antigen delivery kinetics can profoundly influence B cell responses and
should be critically considered in rational vaccine design, particularly for difficult neutralizing …
should be critically considered in rational vaccine design, particularly for difficult neutralizing …
[HTML][HTML] A glycolipid adjuvant, 7DW8-5, enhances CD8+ T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates
…, CD Andrews, J McManus, BF Grasperge… - PloS one, 2013 - journals.plos.org
A key strategy to a successful vaccine against malaria is to identify and develop new
adjuvants that can enhance T-cell responses and improve protective immunity. Upon co-…
adjuvants that can enhance T-cell responses and improve protective immunity. Upon co-…
Once-weekly oral dosing of MK-8591 protects male rhesus macaques from intrarectal challenge with SHIV109CP3
…, H Mohri, A Horowitz, BF Grasperge… - The Journal of …, 2020 - academic.oup.com
… Brooke F Grasperge , Brooke F Grasperge … Bernard, Chasity D Andrews, Hiroshi Mohri,
Amir Horowitz, Brooke F Grasperge, James L Blanchard, Tao Niu, Li Sun, Kerry Fillgrove, Daria J …
Amir Horowitz, Brooke F Grasperge, James L Blanchard, Tao Niu, Li Sun, Kerry Fillgrove, Daria J …
Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies
…, PD Kwong, J Arthos, C Cicala, BF Grasperge… - Science translational …, 2021 - science.org
Anti-HIV broadly neutralizing antibodies (bNAbs) may favor development of antiviral immunity
by engaging the immune system during immunotherapy. Targeting integrin α 4 β 7 with an …
by engaging the immune system during immunotherapy. Targeting integrin α 4 β 7 with an …
[HTML][HTML] Gut microbiome changes associated with epithelial barrier damage and systemic inflammation during antiretroviral therapy of chronic SIV infection
…, EM Walker, N Slisarenko, GL Gerrets, BF Grasperge… - Viruses, 2021 - mdpi.com
Gut dysbiosis is a common feature associated with the chronic inflammation of HIV infection.
Toward understanding the interplay of chronic treated HIV infection, dysbiosis, and systemic …
Toward understanding the interplay of chronic treated HIV infection, dysbiosis, and systemic …