ToppGene Suite ( http://toppgene.cchmc.org ; this web site is free and open to all users and
does not require a login to access) is a one-stop portal for (i) gene list functional enrichment, (…

Eosinophilic esophagitis (EE) is an emerging disorder with a poorly understood pathogenesis.
In order to define disease mechanisms, we took an empirical approach analyzing …

Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling
is associated with hyperimmune activation and disease progression in persistent infections. …

Lineage mapping has identified both proliferative and quiescent intestinal stem cells, but the
molecular circuitry controlling stem cell quiescence is incompletely understood. By lineage …

Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute
myocardial infarction (MI) and to mediate long-standing fibrosis with chronic disease. …

Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …

Background Stricturing and penetrating complications account for substantial morbidity and
health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict …

We report a database of genes responsive to the Myc oncogenic transcription factor. The
database Myc Target Gene prioritizes candidate target genes according to experimental …

The structure and function of the human brain are highly stereotyped, implying a conserved
molecular program responsible for its development, cellular structure and function. We …

Apolipoprotein E (apoE) and clusterin can influence structure, toxicity, and accumulation of
the amyloid-β (Aβ) peptide in brain. Both molecules may also be involved in Aβ metabolism …