User profiles for Bruce R Conklin

Bruce Conklin

Investigator Gladstone and Professor at UCSF
Verified email at gladstone.ucsf.edu
Cited by 27789

Integration of biological networks and gene expression data using Cytoscape

…, AR Pico, A Vailaya, PL Wang, A Adler, BR Conklin… - Nature protocols, 2007 - nature.com
Cytoscape is a free software package for visualizing, modeling and analyzing molecular and
genetic interaction networks. This protocol explains how to use Cytoscape to analyze the …

GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways

…, N Salomonis, K Vranizan, SC Lawlor, BR Conklin - Nature …, 2002 - nature.com
Fig. 1 Fatty-acid degradation pathway adapted from a view in GenMAPP. Each box represents
a gene. For the interactive output of this MAPP and other MAPPs from GenMAPP, see …

[HTML][HTML] MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data

…, KD Dahlquist, K Vranizan, SC Lawlor, BR Conklin - Genome biology, 2003 - Springer
MAPPFinder is a tool that creates a global gene-expression profile across all areas of biology
by integrating the annotations of the Gene Ontology (GO) Project with the free software …

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

BR Conklin, Z Farfel, KD Lustig, D Julius, HR Bourne - Nature, 1993 - nature.com
AGONIST-BOUND receptors activate heterotrimeric (αβγ) G proteins by catalysing replacement
of GDP bound to the α-subunit by GTP 1–5 . Mutations in the C terminus of the α-subunit …

[HTML][HTML] WikiPathways: pathway editing for the people

…, T Kelder, MP Van Iersel, K Hanspers, BR Conklin… - PLoS …, 2008 - journals.plos.org
… Contributed equally to this work with: Alexander R Pico, Thomas Kelder … Contributed
equally to this work with: Alexander R Pico, Thomas Kelder … We thank Susan Coort, Nathan …

[PDF][PDF] MicroRNA regulation of cell lineages in mouse and human embryonic stem cells

…, RF Yeh, JE Fish, EC Hsiao, RJ Schwartz, BR Conklin… - Cell stem cell, 2008 - cell.com
Cell fate decisions of pluripotent embryonic stem (ES) cells are dictated by activation and
repression of lineage-specific genes. Numerous signaling and transcriptional networks …

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

…, MA Mandegar, MP Olvera, LA Gilbert, BR Conklin… - Science, 2017 - science.org
INTRODUCTION The human genome contains tens of thousands of loci that produce long
noncoding RNAs (lncRNAs), transcripts that have no apparent protein-coding potential. A …

WikiPathways: building research communities on biological pathways

…, K Hanspers, M Kutmon, BR Conklin… - Nucleic acids …, 2012 - academic.oup.com
Here, we describe the development of WikiPathways ( http://www.wikipathways.org ), a public
wiki for pathway curation, since it was first published in 2008. New features are discussed, …

Interfacing silicon nanowires with mammalian cells

W Kim, JK Ng, ME Kunitake, BR Conklin… - Journal of the American …, 2007 - ACS Publications
We present the first demonstration of a direct interface of silicon nanowires with mammalian
cells such as mouse embryonic stem (mES) cells and human embryonic kidney (HEK 293T) …

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

AD Federman, BR Conklin, KA Schrader, RR Reed… - Nature, 1992 - nature.com
AGONIST-BOUND receptors activate heterotrimeric (αβγ) G proteins by catalysing replacement
by GTP of GDP bound to the a subunit, resulting in dissociation of α-GTP from the βγ …