Chronic activation of the immune system is a hallmark of progressive HIV infection and better
predicts disease outcome than plasma viral load, yet its etiology remains obscure. Here we …

The immune response plays an important role in staving off cancer; however, mechanisms
of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or …

We previously demonstrated that autologous natural killer (NK)–cell therapy after
hematopoietic cell transplantation (HCT) is safe but does not provide an antitumor effect. We …

Acute graft-versus-host disease (aGVHD) is associated with high risk of morbidity and mortality
and is a common complication after double umbilical cord blood (UCB) transplantation. …

Immune regulatory CD4 + CD25 + cells play a vital role in the induction and maintenance of
self-tolerance and the prevention of autoimmunity. Recently, CD4 + CD25 + cells have been …

The potential benefits of unrelated donor marrow transplantation are offset by the immunologic
complications of graft-versus-host disease (GVHD) and infection. Therefore, we used …

Background Oral mucositis is a complication of intensive chemotherapy and radiotherapy with
no effective treatment. We tested the ability of palifermin (recombinant human keratinocyte …

Limited umbilical cord blood (UCB) cell dose compromises the outcome of adult UCB
transplantation. Therefore, to augment graft cell dose, we evaluated the safety of the combined …

Allogeneic haematopoietic stem cell transplantation is used to treat a variety of disorders,
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …

When T cells from a bone marrow donor begin to attack the host within 3 months after
hematopoietic-cell transplantation, acute graft-versus-host disease results. The disease mainly …