Previous studies demonstrated that opioid receptor activation mimics the cardioprotective
effect of ischemic preconditioning via K ATP channels in the intact heart. However, it is …

The A 3 adenosine receptor (A 3 AR) coupled to G i (inhibitory regulative guanine nucleotide-binding
protein) mediates anti-inflammatory, anticancer and anti-ischemic protective effects…

It has long been assumed that the primary influences regulating cardiac contractility are the
extent of mechanical loading of muscle fibers and the activity of the autonomic nervous …

Phospholipase D (PLD) is a key facilitator of multiple types of membrane vesicle trafficking
events. Two PLD isoforms, PLD1 and PLD2, exist in mammals. Initial studies based on …

Adenosine released during cardiac ischemia exerts a potent, protective effect in the heart. A
newly recognized adenosine receptor, the A 3 subtype, is expressed on the cardiac …

Activation of a cardiac myocyte P2X4 receptor protects against heart failure. 5′-Phosphonate
and 5′-phosphate analogues of AMP containing a (N)-methanocarba (bicyclo[3.1.0]…

Rapid screening of red blood cells for active infection of COVID-19 is presented using a
compact and field-portable, 3D-printed shearing digital holographic microscope. Video …

Stroke remains a leading cause of disability in the United States. Despite recent advances,
interventions to reduce damage and enhance recovery after stroke are lacking. P2X4R, a …

P2X receptor activation protects in heart failure models. MRS2339 3, a 2-chloro-AMP
derivative containing a (N)-methanocarba (bicyclo[3.1.0]hexane) system, activates this …

Background— Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1) is a potential
therapeutic target for cardiovascular diseases, but its role in angiogenesis remains …