There is a growing appreciation that adult hippocampal neurogenesis plays a role in emotional
and cognitive processes related to psychiatric disorders. Although many studies have …

RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage
response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it …

Accumulating evidence suggests that certain gut microbiota have antidepressant-like behavioural
effects and that the microbiota can regulate neurogenesis and the expression of brain-…

Liquid–liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving
force underlying the formation of membrane-less organelles. Such biomolecular condensates …

Stress-related psychiatric disorders such as depression are among the leading causes of
morbidity and mortality. Considering that many individuals fail to respond to currently available …

Hippocampal neurogenesis has been shown to play roles in learning, memory, and stress
responses. These diverse roles may be related to a functional segregation of the …

RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage
response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it …

… FUS knock-out sensitises human cells to DNA damage and induces R-loop formation …
measured R-loop levels in HeLa wild type and FUS-KO cells by confocal microscopy using …

Accumulating evidence suggests that the hippocampus is functionally segregated along its
longitudinal axis into a dorsal (dHi) sub-region, shown to play roles in learning & memory …

Here we describe a protocol for the generation of site-specific DNA damage, including double
and single strand breaks, using the 405 nm laser of a confocal microscope in cells pre-…