Disruptions in iron homeostasis from both iron deficiency and overload account for some of
the most common human diseases. Iron metabolism is balanced by two regulatory systems, …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2 × 10 15 iron
atoms every second to maintain adequate erythropoiesis. These numbers translate into 20 …

The regulation and maintenance of systemic iron homeostasis is critical to human health.
Iron overload and deficiency diseases belong to the most common nutrition-related …

Hypoxia stimulates erythropoiesis, the major iron-utilization pathway. We report the discovery
of a conserved, functional iron-responsive element (IRE) in the 5′ untranslated region of …

In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair. …

The serum ferritin concentration is a clinical parameter measured widely for the differential
diagnosis of anemia. Its levels increase with elevations of tissue iron stores and with …

Studies on the control of eukaryotic translation initiation by a cap‐independent recruitment of
the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome …

Iron regulatory protein 2 (IRP2)-deficient mice have been reported to suffer from late-onset
neurodegeneration by an unknown mechanism. We report that young adult Irp2 -/- mice …

Red blood cell production is a finely tuned process that requires coordinated oxygen- and
iron-dependent regulation of cell differentiation and iron metabolism. Here, we show that …

Iron regulatory proteins (IRPs) orchestrate the posttranscriptional regulation of critical iron
metabolism proteins at the cellular level. Redundancy between IRP1 and IRP2 associated …