Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…

Myeloid cells comprise the majority of immune cells in tumors, contributing to tumor growth
and therapeutic resistance. Incomplete understanding of myeloid cells response to tumor …

In aggressive non-Hodgkin’s lymphoma (NHL), constitutive apoptosis of a proportion of the
tumor cell population can promote net tumor growth. This is associated with the accumulation …

Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …

Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor-…

Late prenatal development of the human neocortex encompasses a critical period of
gliogenesis and cortical expansion. However, systematic single-cell analyses to resolve cellular …

The set of proteins required for mitotic division remains poorly characterized. Here, an
extensive series of correlation analyses of human and mouse transcriptomics data were …

Monocytes and monocyte-derived macrophages (MDMs) from blood circulation infiltrate
glioblastoma (GBM) and promote growth. Here, we show that PDGFB-driven GBM cells induce …

Background Cell division is central to the physiology and pathology of all eukaryotic organisms.
The molecular machinery underpinning the cell cycle has been studied extensively in a …

Here, we leveraged a large neoadjuvant PD-1 blockade trial in patients with hepatocellular
carcinoma (HCC) to search for correlates of response to immune checkpoint blockade (ICB) …