The prevention and treatment of prevalent infectious diseases and tumors should benefit from
improvements in the induction of antigen-specific T cell immunity. To assess the potential …

Regulatory T (Treg) cells suppress immune responses to a broad range of non-microbial
and microbial antigens and indirectly limit immune inflammation-inflicted tissue damage by …

Identification of immune effectors and the post-translational modifications that control their
activity is essential for dissecting mechanisms of immunity. Here we demonstrate that the …

Adaptive immune responses are tailored to different types of pathogens through differentiation
of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 (T H 1), …

Current human immunodeficiency virus (HIV) vaccine approaches emphasize prime boost
strategies comprising multiple doses of DNA vaccine and recombinant viral vectors. We are …

The majority of deaths following influenza virus infection result from secondary bacterial
superinfection, most commonly caused by Streptococcus pneumoniae . Several models have …

T-cell receptor (TCR) signalling has a key role in determining T-cell fate. Precursor cells
expressing TCRs within a certain low-affinity range for complexes of self-peptide and major …

10.7554/eLife.33057.001 Dynamic post-transcriptional control of RNA expression by RNA-binding
proteins (RBPs) is critical during immune response. ZFP36 RBPs are prominent …

Migratory lung dendritic cells (DCs) transport viral antigen from the lungs to the draining
mediastinal lymph nodes (MLNs) during influenza virus infection to initiate the adaptive immune …

TLR signaling leads to dendritic cell (DC) maturation and immunity to diverse pathogens. The
stimulation of TLRs by conserved viral structures is the only described mechanism leading …