Cellular responses to DNA damage are mediated by a number of protein kinases, including
ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the …

In response to nutrients, energy sufficiency, hormones, and mitogenic agents, S6K1
phosphorylates several targets linked to translation. However, the molecular mechanisms whereby …

Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either of the
two tumor suppressor genes TSC1 or TSC2, which encode hamartin and tuberin, …

The BRCT repeats of the breast and ovarian cancer predisposition protein BRCA1 are
essential for tumor suppression. Phosphopeptide affinity proteomic analysis identified a protein, …

Fanconi anemia (FA) is a developmental and cancer-predisposition syndrome caused by
mutations in genes controlling DNA interstrand crosslink repair. Several FA proteins form a …

To maximize advantages and reduce costs associated with life as an interdependent community
of cells, multicellular organisms have evolved common mechanisms to regulate the life …

Proper development of the mammalian brain requires the precise integration of numerous
temporally and spatially regulated stimuli. Many of these signals transduce their cues via the …

In humans, seven evolutionarily conserved genes that cause the cilia-related disorder
Bardet-Biedl syndrome (BBS) encode proteins that form a complex termed the BBSome. The …

Background: Growth factors activate an array of cell survival signaling pathways. Mitogen-activated
protein (MAP) kinases transduce signals emanating from their upstream activators …

Background: Disabled-1 (Dab1) is an intracellular adaptor protein that regulates migrations
of various classes of neurons during mammalian brain development. Dab1 function depends …