Mesenchymal stromal cell (MSC)-based cell therapy in acute respiratory diseases is based
on MSC secretion of paracrine factors. Several strategies have proposed to improve this are …

Mesenchymal stromal cell (MSC)-based therapies for inflammatory diseases rely mainly on
the paracrine ability to modulate the activity of macrophages. Despite recent advances, there …

Cell response to force regulates essential processes in health and disease. However, the
fundamental mechanical variables that cells sense and respond to remain unclear. Here we …

Increasing evidence shows that lungs can be damaged by inhalation of nanoparticles (NPs)
at environmental and occupational settings. Recent findings have associated the exposure …

Hypoxia is a common characteristic of many solid tumors that has been associated with
tumor aggressiveness. Limited diffusion of oxygen generates a gradient of oxygen availability …

The extracellular matrix (ECM) of the lung provides physical support and key mechanical
signals to pulmonary cells. Although lung ECM is continuously subjected to different stretch …

Background: Tissue hypoxia-reoxygenation characterizes obstructive sleep apnea (OSA), a
very prevalent respiratory disease associated with increased cardiovascular morbidity and …

Intermittent hypoxia (IH) has been implicated in the cardiovascular consequences of obstructive
sleep apnea (OSA). However, the lack of suitable experimental systems has precluded …

Since the emergence of 3D bioprinting technology, both synthetic and natural materials
have been used to develop bioinks for producing cell-laden cardiac grafts. To this end, …

Background: Heart failure (HF) – a very prevalent disease with high morbidity and mortality
– usually presents with diastolic dysfunction. Although post-menopause women are at …