The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters host cells
via an interaction between its Spike protein and the host cell receptor angiotensin-converting …

INTRODUCTION The emergence of three lethal coronaviruses in <20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, …

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by
binding of the viral Spike protein to host receptor angiotensin-converting enzyme 2 (ACE2), …

Amphiphilic copolymers capable of extracting membrane proteins directly from lipid bilayers
into "native nanodiscs" promise a simpler membrane protein sample preparation procedure …

Hedgehog signalling is fundamental to embryonic development and postnatal tissue
regeneration 1 . Aberrant postnatal Hedgehog signalling leads to several malignancies, including …

Our sense of smell enables us to navigate a vast space of chemically diverse odour molecules.
This task is accomplished by the combinatorial activation of approximately 400 odorant G …

The neuropeptide substance P (SP) is important in pain and inflammation. SP activates the
neurokinin-1 receptor (NK1R) to signal via G q and G s proteins. Neurokinin A also activates …

Thyroid hormones are vital in metabolism, growth and development 1 . Thyroid hormone
synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR) 2 . In …

Without an effective prophylactic solution, infections from SARS-CoV-2 continue to rise
worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host cells …

In vitro antibody selection against pathogens from naïve combinatorial libraries can yield
various classes of antigen-specific binders that are distinct from those evolved from natural …