Inhibitory molecules associated with myelin and the glial scar limit axon regeneration in the
adult central nervous system (CNS), but the underlying signaling mechanisms of …

Alternative splicing provides a means to increase the complexity of gene function in
numerous biological processes, including nervous system wiring. Navigating axons switch …

Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the
brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the …

Rapid cell type identification by new genomic single-cell analysis methods has not been met
with efficient experimental access to these cell types. To facilitate access to specific neural …

Background Heparan sulfate proteoglycans (HSPGs) use highly sulfated polysaccharide
side-chains to interact with several key growth factors and morphogens, thereby regulating their …

Viral genetic tools that target specific brain cell types could transform basic neuroscience
and targeted gene therapy. Here, we use comparative open chromatin analysis to identify …

Delivering genes to and across the brain vasculature efficiently and specifically across
species remains a critical challenge for addressing neurological diseases. We have evolved …

The mammalian brain contains tremendous structural and genetic complexity that is vital for
its function. The elucidation of gene expression profiles in the brain, coupled with the …

Dopamine is broadly implicated in fear-related processes, yet we know very little about
signaling dynamics in these neurons during active fear conditioning. We describe the direct …

The dopamine D1 receptor (D1R) facilitates reward acquisition and its alteration leads to
profound learning deficits. However, its minimal functional circuit requirement is unknown. …