HOXB13 is a member of the homeodomain family of sequence-specific transcription factors
and, together with the androgen receptor (AR), plays a critical role in the normal …

While patients with advanced prostate cancer initially respond favorably to androgen ablation
therapy, most experience a relapse of the disease within 1–2 years. Although hormone-…

One subclass of antiestrogens, the selective estrogen receptor down-regulators (SERDs),
have received considerable attention of late as they competitively inhibit estrogen binding and …

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease of the lung vasculature
for which the molecular etiologies are unclear. Specific metabolic alterations have been …

Bladder cancer (BCa) is a common malignancy worldwide and has a high probability of
recurrence after initial diagnosis and treatment. As a result, recurrent surveillance, primarily …

Metabolomics is the untargeted measurement of the metabolome, which is composed of the
complement of small molecules detected in a biological sample. As such, metabolomic …

Reducing premature mortality associated with age-related chronic diseases, such as cancer
and cardiovascular disease, is an urgent priority. We report early results using genomics in …

Cell populations with differing proliferative, stem-like and tumorigenic states co-exist in most
tumors and especially malignant gliomas. Whether metabolic variations can drive this …

Advanced prostate cancers preferentially metastasize to bone, suggesting that this tissue
produces factors that provide a suitable microenvironment for prostate cancer cells. Recently, it …

Background: Polyamine levels are intricately controlled by biosynthetic, catabolic enzymes
and antizymes. The complexity suggests that minute alterations in levels lead to profound …