Direct comparisons of human and non-human primate brains can reveal molecular pathways
underlying remarkable specializations of the human brain. However, chimpanzee tissue is …

One goal of human genetics is to understand how the information for precise and dynamic
gene expression programs is encoded in the genome. The interactions of transcription factors …

The advent of induced pluripotent stem cells (iPSCs) revolutionized human genetics by
allowing us to generate pluripotent cells from easily accessible somatic tissues. This technology …

10.7554/eLife.07103.001 Comparative genomics studies in primates are restricted due to
our limited access to samples. In order to gain better insight into the genetic processes that …

Induced pluripotent stem cells (iPSCs) are an essential tool for studying cellular differentiation
and cell types that are otherwise difficult to access. We investigated the use of iPSCs and …

Comparative genomic studies in primates have the potential to reveal the genetic and mechanistic
basis for human specific traits. These studies may also help us better understand inter-…

Comparative studies of great apes provide a window into our evolutionary past, but the extent
and identity of cellular differences that emerged during hominin evolution remain largely …

Inter-individual variation in gene expression has been shown to be heritable and is often
associated with differences in disease susceptibility between individuals. Many studies focused …

Background There is substantial interest in the evolutionary forces that shaped the regulatory
framework in early human development. Progress in this area has been slow because it is …

Renewable in vitro cell cultures, such as lymphoblastoid cell lines (LCLs), have facilitated
studies that contributed to our understanding of genetic influence on human traits. However, …