Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein that binds to itself and
cellular partners through its four-point-one, ezrin, radixin, moesin (FERM) domain. Recent …

Focal adhesion kinase (FAK) promotes anti-tumor immune evasion. Specifically, the kinase
activity of nuclear-targeted FAK in squamous cell carcinoma (SCC) cells drives exhaustion of …

Networks of actin filaments, controlled by the Arp2/3 complex, drive membrane protrusion
during cell migration. How integrins signal to the Arp2/3 complex is not well understood. Here, …

Src tyrosine kinase expression and activity are elevated during colon cancer progression.
How this contributes to the malignant phenotype is not fully understood. We show that in …

We have generated mice with a floxed fak allele under the control of keratin-14-driven Cre
fused to a modified estrogen receptor (CreER T2 ). 4-Hydroxy-tamoxifen treatment induced …

Reverse phase protein array (RPPA) technology introduced a miniaturized "antigen-down"
or "dot-blot" immunoassay suitable for quantifying the relative, semi-quantitative or …

Here we describe a mechanism that cancer cells use to survive when flux through the Src/FAK
pathway is severely perturbed. Depletion of FAK, detachment of FAK-proficient cells or …

Most cancer-related deaths are due to the development of metastatic disease, and several
new molecularly targeted agents in clinical development have the potential to prevent …

A fundamental question in cell biology concerns how cells respond to their environment by
polarizing after sensing directional cues. This requires the differential localization of protein …

Current US Food and Drug Administration-approved chimeric antigen receptor (CAR) T
cells harbor the T cell receptor (TCR)-derived ζ chain as an intracellular activation domain in …