Background Vascular endothelial growth factor (VEGF) is well known for its role in normal and
pathologic neovascularization. However, a growing body of evidence indicates that VEGF …

This study was designed to determine whether adult mouse induced pluripotent stem cells (iPSCs),
could be used to produce retinal precursors and subsequently photoreceptor cells …

Purpose To devise a comprehensive multiplatform genetic testing strategy for inherited
retinal disease and to describe its performance in 1000 consecutive families seen by a single …

Corneal epithelial homeostasis and regeneration are sustained by limbal stem cells (LSCs)
1 , 2 , 3 , and LSC deficiency is a major cause of blindness worldwide 4 . Transplantation is …

The human retinal pigment epithelium (RPE) and choroid are complex tissues that provide
crucial support to the retina. Disease affecting either of these supportive tissues can lead to …

Age-related macular degeneration (AMD) is a common and devastating disease that can
result in severe visual dysfunction. Over the last decade, great progress has been made in …

Retinitis pigmentosa (RP) is a genetically heterogeneous heritable disease characterized
by apoptotic death of photoreceptor cells. We used exome sequencing to identify a …

Nerve growth factor (NGF) and insulin‐like growth factor‐1 (IGF‐1) play an important role in
promoting axonal growth from dorsal root ganglion (DRG) neurons. Adult DRG neurons …

10.7554/eLife.00824.001 Next-generation and Sanger sequencing were combined to
identify disease-causing USH2A mutations in an adult patient with autosomal recessive RP. …

Mutations in ABCA4 cause Stargardt disease and other blinding autosomal recessive retinal
disorders. However, sequencing of the complete coding sequence in patients with clinical …