INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

… Several APP mutations cluster at or after the C-terminal portion of the Aβ domain. These
mutations alter γ-secretase function, leading to a shift in APP processing that increases the …

Previous genome-wide association studies (GWASs) of stroke — the second leading cause
of death worldwide — were conducted predominantly in populations of European ancestry 1 …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …

Stroke is a complex disease and one of the main causes of morbidity and mortality among the
adult population. A huge variety of factors is known to influence patient outcome, including …

APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases
brain amyloid-β pathology relative to other ApoE isoforms 1 . However, whether APOE …