Cryptophyte and chlorarachniophyte algae are transitional forms in the widespread secondary
endosymbiotic acquisition of photosynthesis by engulfment of eukaryotic algae. Unlike …

Despite a deeper molecular understanding, human glioblastoma remains one of the most
treatment refractory and fatal cancers. It is known that the presence of macrophages and …

… c, Association of noncoding clusters in regulatory regions of TERT and AP2A1 with gene …
Box plots in c represent the median, upper and lower quartiles of the distribution, and whiskers …

Background Recent advances are enabling delivery of precision genomic medicine to
cancer clinics. While the majority of approaches profile panels of selected genes or hotspot …

… C. japonica has an impressive number of at least 311 introns in its genome (see Figure 2),
surpassing the record previously held by euglenophyceans; the most intron-rich ptDNA docu…

… CJ Grisdale reports grants from NIH during the conduct of the study. RA Moore reports grants
from Genome Canada, TFRI, and BC Cancer Foundation during the conduct of the study. J.-…

CIViC (Clinical Interpretation of Variants in Cancer; civicdb.org) is a crowd-sourced, public
domain knowledgebase composed of literature-derived evidence characterizing the clinical …

… C. merolae has a highly reduced set of 43 identifiable core … , suggesting that splicing in C.
merolae may occur without the … compositional variability during splicing in C. merolae than in …

… (C) DEGs up-regulated in BTICs relative to xenografts. (D) DEGs up-regulated in
xenografts … All these MSH6 mutations are G>A or C>T, consistent with the pattern of TMZ-introduced …

Manually curated variant knowledgebases and their associated knowledge models are
serving an increasingly important role in distributing and interpreting variants in cancer. These …