The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-coupled
quality control system that recognizes and degrades aberrant mRNAs with truncated open …

… C-protein. Cycloheximide was present to inhibit viral protein synthesis. While we could readily
record an increase in the fluorescence signal of the C-… of Upf1 (Figure S2C). This indicated …

… c, d, Tracing for ten days starting either at birth (P0) (c) or P30 (d) revealed different clonality
patterns. e, Clonal size was quantified for various tracing periods, with columns containing …

Fused in sarcoma ( FUS ) is a ubiquitously expressed RNA ‐binding protein proposed to
function in various RNA metabolic pathways, including transcription regulation, pre‐ mRNA …

Simple Summary Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by a
progressive paralysis due to the loss of particular neurons in our nervous system called motor …

… -(F1-edited, F3-filtered) NOESY HSQC spectra recorded with 15 N– 13 C-labelled protein
and unlabelled RNA or with 15 N– 13 C-labelled RNA and unlabelled protein in 100% D 2 O …

… However, a C to T nucleotide transition in exon 7 of the SMN2 gene disrupts an exonic
splicing enhancer and leads to alternative splicing, in which a majority of SMN2 transcripts lack …

… -20, Santa Cruz Biotechnology, Santa Cruz, CA) had been raised against a peptide from the
C-terminus of CstF-64 that is identical in CstF-64Tau, we wanted to find out whether this 70-…

… hours at 4C before SA purification. (C) Extracts 1 and 2 were mixed with the HB-UPF1 (3, 4)
and HB*-UPF1 (5, 6) expressing extracts followed by incubation for 16 hours at 4C. The total …

Endurance exercise promotes skeletal muscle vascularization, oxidative metabolism, fiber-type
switching, and neuromuscular junction integrity. Importantly, the metabolic and …