User profiles for Cécile Alanio
Cécile AlanioMD, PhD, Parker Bridge Scholar Verified email at curie.fr Cited by 5595 |
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …
PD-1–expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer
Head and neck cancers positive for human papillomavirus (HPV) have a more favorable
clinical outcome than HPV-negative cancers, but it is unknown why this is the case. We …
clinical outcome than HPV-negative cancers, but it is unknown why this is the case. We …
Pembrolizumab for B-cell lymphomas relapsing after or refractory to CD19-directed CAR T-cell therapy
CD19-directed chimeric antigen receptor–modified (CAR T) T cells achieve durable remissions
in about 30% to 40% of relapsed/refractory large B-cell lymphomas. T-cell exhaustion …
in about 30% to 40% of relapsed/refractory large B-cell lymphomas. T-cell exhaustion …
[PDF][PDF] Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within
the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been …
the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been …
[HTML][HTML] CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and
the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 …
the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 …
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children, …
with fewer hospitalizations and often milder disease than in adults. A subset of children, …
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
The quantification and characterization of circulating immune cells provide key indicators of
human health and disease. To identify the relative effects of environmental and genetic …
human health and disease. To identify the relative effects of environmental and genetic …
Enumeration of human antigen–specific naive CD8+ T cells reveals conserved precursor frequencies
C Alanio, F Lemaitre, HKW Law… - Blood, The Journal …, 2010 - ashpublications.org
The number of antigen-specific naive CD8 + T cells is believed to be important in the shaping
of adaptive immune responses, and is predictive for the magnitude of priming responses in …
of adaptive immune responses, and is predictive for the magnitude of priming responses in …
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated
potential for treatment of various cancers 1 , 2 , 3 , 4 , 5 , 6 – 7 . However, little is known …
potential for treatment of various cancers 1 , 2 , 3 , 4 , 5 , 6 – 7 . However, little is known …
[HTML][HTML] Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 …
…, J Xu, PF Gherardini, J Karakunnel, R Mick, C Alanio… - Nature medicine, 2022 - nature.com
Chemotherapy combined with immunotherapy has improved the treatment of certain solid
tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma (PDAC). …
tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma (PDAC). …