Long-term allograft survival generally requires lifelong immunosuppression (IS). Rarely,
recipients display spontaneous “operational tolerance” with stable graft function in the absence …

Background. Although immunosuppression withdrawal in kidney recipients usually leads to
rejection, in some patients it does not, leading to a state of clinical operational tolerance. …

Several transplant patients maintain stable kidney graft function in the absence of
immunosuppression. Here we compared the characteristics of their peripheral B cells to that of others …

TLR repertoire and in vitro responsiveness of blood classical DC subsets. Human blood DCs
encompass pDCs and two subsets of mDCs: CD1c + mDCs and CD141 + mDCs. The rare …

Multiple sclerosis (MS) is a chronic inflammatory disease that results in demyelination in the
central nervous system, and a defect in the regulatory function of CD4 + CD25 high T cells …

Chronic rejection (CR) is a major cause of long‐term graft loss that would be avoided by the
induction of tolerance. We previously showed that renal transplant patients with CR have …

The hallmark of chronic rejection is the occlusion of the artery lumen by intima hyperplasia as
a consequence of leukocyte infiltration and vascular smooth muscle cell (VSMC) migration …

It remains unknown what causes inflammatory bowel disease (IBD), including signaling
networks perpetuating chronic gastrointestinal inflammation in Crohn’s disease (CD) and …

A substantial proportion of long-term kidney graft recipients, including those with a stable renal
function in the absence of immunosuppressive therapy, present a skewed T cell receptor (…

Background Clinical benefit from programmed cell death 1 receptor (PD-1) inhibitors relies
on reinvigoration of endogenous antitumor immunity. Nonetheless, robust immunological …