Penaeidins, antimicrobial peptides with chitin-binding activity, are produced and stored in shrimp granulocytes and released after microbial challenge

D Destoumieux, M Muñoz, C Cosseau… - Journal of cell …, 2000 - journals.biologists.com
Penaeidins are members of a new family of antimicrobial peptides isolated from a crustacean,
which present both Gram-positive antibacterial and antifungal activities. We have studied …

[HTML][HTML] Genes Related to Ion-Transport and Energy Production Are Upregulated in Response to CO2-Driven pH Decrease in Corals: New Insights from …

…, D Zoccola, E Tambutté, C Grunau, C Cosseau… - PloS one, 2013 - journals.plos.org
Since the preindustrial era, the average surface ocean pH has declined by 0.1 pH units and
is predicted to decline by an additional 0.3 units by the year 2100. Although subtle, this …

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

F Dubois, S Caby, F Oger, C Cosseau… - Molecular and …, 2009 - Elsevier
In order to explore the conservation/divergence of transcriptional regulation in the
platyhelminth parasite Schistosoma mansoni, we are studying the structures and functions of …

Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome

…, MA Leroy, P Haffner, B Petton, C Cosseau… - Science …, 2023 - science.org
Disease emergence is accelerating with global changes. Understanding by which mechanisms
host populations can rapidly adapt will be crucial for management practices. Pacific …

Complexities of targeting innate immunity to treat infection

KL Brown, C Cosseau, JL Gardy, REW Hancock - TRENDS in Immunology, 2007 - cell.com
Innate immunity is an ancient form of host defence that is activated rapidly to enable, through
a multiplicity of effector mechanisms, defence against a broad spectrum of microbial threats…

[HTML][HTML] Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection

…, J Vidal-Dupiol, C Grunau, G Mitta, C Cosseau - Microbiome, 2022 - Springer
Background The interaction of organisms with their surrounding microbial communities
influences many biological processes, a notable example of which is the shaping of the immune …

Applying ecological and evolutionary theory to cancer: a long and winding road

…, B Roche, C Grunau, C Cosseau… - Evolutionary …, 2013 - Wiley Online Library
Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with
somatic cellular selection and evolution being the fundamental processes leading to …

[HTML][HTML] Controlled Chaos of Polymorphic Mucins in a Metazoan Parasite (Schistosoma mansoni) Interacting with Its Invertebrate Host (Biomphalaria glabrata)

…, R Emans, IM Cesari, C Cosseau… - PLoS neglected …, 2008 - journals.plos.org
Invertebrates were long thought to possess only a simple, effective and hence non-adaptive
defence system against microbial and parasitic attacks. However, recent studies have …

An example of molecular co-evolution: reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions

Y Moné, AC Ribou, C Cosseau, D Duval… - International journal for …, 2011 - Elsevier
The co-evolution between hosts and parasites involves huge reciprocal selective pressures
on both protagonists. However, relatively few reports have evaluated the impact of these …

[HTML][HTML] The roles of Dmrt (Double sex/Male-abnormal-3 Related Transcription factor) genes in sex determination and differentiation mechanisms: Ubiquity and …

MAL Picard, C Cosseau… - Comptes …, 2015 - comptes-rendus.academie-sciences …
The Dmrt (Double sex/Male-abnormal-3 Related Transcription factor) genes have been
intensively studied because they represent major transcription factors in the pathways governing …