Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic
physiology across most living organisms. Although such rhythms have been extensively …

Biological rhythms play a fundamental role in the physiology and behavior of most living
organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a …

Obesity and liver diseases are associated with the disruption of the circadian clock that
orchestrates mammalian physiology to optimize nutrient metabolism and storage. Here, we show …

The circadian timing system is critically involved in the maintenance of fluid and electrolyte
balance and BP control. However, the role of peripheral circadian clocks in these homeostatic …

Temporal control of physiology requires the interplay between gene networks involved in
daily timekeeping and tissue function across different organs. How the circadian clock …

The circadian clock in animals orchestrates widespread oscillatory gene expression programs,
which underlie 24-h rhythms in behavior and physiology. Several studies have shown the …

In mammals, many aspects of metabolism are under circadian control. At least in part, this
regulation is achieved by core-clock or clock-controlled transcription factors whose abundance …

In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) orchestrates a
genomic and metabolic response required for homeostasis during fasting. This includes the …

The circadian clock is a hierarchical timing system regulating most physiological and behavioral
functions with a period of approximately 24 h in humans and other mammalian species. …

Objective Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows
diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around …