Hsp70 molecular chaperones play a variety of functions in every organism, cell type and
organelle, and their activities have been implicated in a number of human pathologies, ranging …

To the Editor—Animal behavior is increasingly being recorded in systematic imaging studies
that generate large datasets. To maximize the usefulness of these data, there is a need for …

In its natural habitat, C. elegans encounters a wide variety of microbes, including food,
commensals and pathogens. To be able to survive long enough to reproduce, C. elegans has …

Background The cytosol of most eukaryotic cells contains multiple highly conserved Hsp70
orthologs that differ mainly by their spatio-temporal expression patterns. Hsp70s play …

Ageing affects a wide range of phenotypes at all scales, but an objective measure of ageing
remains challenging, even in simple model organisms. To measure the ageing process, we …

The yeast Saccharomyces cerevisiae has been used as a model for fungal biofilm formation
due to its ability to adhere to plastic surfaces and to form mats on low-density agar petri …

The enzyme TDO (tryptophan 2,3-dioxygenase; TDO-2 in Caenorhabditis elegans) is a
potential therapeutic target to cancer but is also thought to regulate proteotoxic events seen in …

Protein aggregation is associated with age-related neurodegenerative disorders, such as
Alzheimer's and polyglutamine diseases. As a causal relationship between protein …

The yeast Saccharomyces cerevisiae is able to form complex multicellular structures called
mats on low-density agar Petri plates. Mat formation strictly depends on Flo11p, a cell …

Ageing affects a wide range of phenotypes at all scales, but an objective measure of ageing
remains challenging, even in simple model organisms. We assumed that a wide range of …