Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

C Szabo, C Ransy, K Módis… - British journal of …, 2014 - Wiley Online Library
Until recently, hydrogen sulfide ( H 2 S ) was exclusively viewed a toxic gas and an environmental
hazard, with its toxicity primarily attributed to the inhibition of mitochondrial C omplex …

[HTML][HTML] Use of H2O2 to Cause Oxidative Stress, the Catalase Issue

C Ransy, C Vaz, A Lombès, F Bouillaud - International journal of …, 2020 - mdpi.com
Addition of hydrogen peroxide (H 2 O 2 ) is a method commonly used to trigger cellular
oxidative stress. However, the doses used (often hundreds of micromolar) are disproportionally …

Mitochondrial retrograde signaling mediated by UCP2 inhibits cancer cell proliferation and tumorigenesis

P Esteves, C Pecqueur, C Ransy, C Esnous, V Lenoir… - Cancer research, 2014 - AACR
Cancer cells tilt their energy production away from oxidative phosphorylation (OXPHOS)
toward glycolysis during malignant progression, even when aerobic metabolism is available. …

New biologically active hydrogen sulfide donors.

T Roger, F Raynaud, F Bouillaud, C Ransy… - … : a European Journal …, 2013 - europepmc.org
Generous donors: The dithioperoxyanhydrides (CH3 COS) 2,(PhCOS) 2, CH3 COSSCO2
Me and PhCOSSCO2 Me act as thiol-activated hydrogen sulfide donors in aqueous buffer …

[HTML][HTML] S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo

…, A Belmellat, A Sennepin, T Vogl, C Ransy… - Nature …, 2022 - nature.com
HIV-1 eradication is hindered by viral persistence in cell reservoirs, established not only in
circulatory CD4 + T-cells but also in tissue-resident macrophages. The nature of macrophage …

The level of H2O2 type oxidative stress regulates virulence of Theileria‐transformed leukocytes

…, N Echebli, M Chaussepied, C Ransy… - Cellular …, 2014 - Wiley Online Library
T heileria annulata infects predominantly macrophages, and to a lesser extent B cells, and
causes a widespread disease of cattle called tropical theileriosis. Disease‐causing infected …

[HTML][HTML] GYY4137-derived hydrogen sulfide donates electrons to the mitochondrial electron transport chain via sulfide: quinone oxidoreductase in endothelial cells

BS Star, EC van der Slikke, C Ransy, A Schmitt… - Antioxidants, 2023 - mdpi.com
The protective effects of hydrogen sulphide (H 2 S) to limit oxidative injury and preserve
mitochondrial function during sepsis, ischemia/reperfusion, and neurodegenerative diseases …

[HTML][HTML] Hepcidin deficiency in mice impairs white adipose tissue browning possibly due to a defect in de novo adipogenesis

JC Deschemin, C Ransy, F Bouillaud, S Chung… - Scientific Reports, 2023 - nature.com
The role of iron in the two major sites of adaptive thermogenesis, namely the beige inguinal (iWAT)
and brown adipose tissues (BAT) has not been fully understood yet. Body iron levels …

[HTML][HTML] UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling

…, C Caradeuc, V Lenoir, M Croyal, C Ransy… - Frontiers in …, 2022 - frontiersin.org
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived
from early T cell progenitors. Since relapsed T-ALL is associated with a poor prognosis …

[HTML][HTML] Positive feedback during sulfide oxidation fine-tunes cellular affinity for oxygen

A Abou-Hamdan, C Ransy, T Roger… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Sulfide (H 2 S in the gas form) is the third gaseous transmitter found in mammals. However,
in contrast to nitric oxide (NO) or carbon monoxide (CO), sulfide is oxidized by a sulfide …