The increasing prevalence of diabetes has resulted in a global epidemic 1 . Diabetes is a
major cause of blindness, kidney failure, heart attacks, stroke and amputation of lower limbs. …

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential
to provide improved cellular models of human disease. However, variable genetic and …

Mutational signatures are imprints of pathophysiological processes arising through tumorigenesis.
We generated isogenic CRISPR–Cas9 knockouts (∆) of 43 genes in human induced …

Loss of IL-10 signaling in macrophages (Mφs) leads to inflammatory bowel disease (IBD).
Induced pluripotent stem cells (iPSCs) were generated from an infantile-onset IBD patient …

The ability to directly uncover the contributions of genes to a given phenotype is fundamental
for biology research. However, ostensibly homogeneous cell populations exhibit large …

The collection sites of human primary tissue samples and the receiving laboratories, where
the human induced pluripotent stem cells (hIPSCs) are derived, are often not on the same site…

The cytotoxic activity of the bacteriophage λ‐holin protein reduces tumour growth rates in
mammary cancer cell xenograft models - Agu - 2006 - The Journal of Gene Medicine - Wiley …

Progressive microcephaly and neurodegeneration are genetically heterogenous conditions,
largely associated with genes that are essential for the survival of neurons. In this study, we …

The bacteriophage‐encoded holin proteins are known to promote bacterial cell lysis by
forming lesions within the cytoplasmic membrane. Recently, we have shown that the …

Worldwide dissemination of antibiotic resistance in bacteria is facilitated by plasmids that
encode postsegregational killing (PSK) systems. These produce a stable toxin (T) and a labile …