Germ-line mutations in components of the Ras/MAPK pathway result in developmental disorders
called RASopathies, affecting about 1/1,000 human births. Rapid advances in genome …

CRISPR/Cas9 has become a powerful tool for genome editing in zebrafish that permits the
rapid generation of loss of function mutations and the knock-in of specific alleles using DNA …

Background Pregnancy increases the risk of acute myocardial infarction (AMI). The purpose
of this study was to examine timing and risk factors for AMI in pregnancy and poor outcome. …

Perturbations to the epigenome are known drivers of tumorigenesis. In melanoma, alterations
in histone methyltransferases that catalyze methylation at histone 3 lysine 9 and histone 3 …

CRISPR/Cas9 has become a powerful tool for genome editing in zebrafish that permits the
rapid generation of loss of function mutations and the knock-in of specific alleles using DNA …

Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have
traditionally been considered separate entities. Defects in the regulation of the complement …

Introduction: Maternal mortality associated with cardiovascular disease is rising in the US. It
is unclear what the contemporary trends for acute myocardial infarction (AMI) and …

… This work was supported by a grant from the National Cancer Institure of Canada ( to MRA).
ER was supported by an Ontario Graduate Scholarship and CML by a Canadian Institutes of …

… Balgobin was the principal author. Revisions and recommendations were made by the …
Balgobin was the principal author. Revisions and recommendations were made by the …

… : IC = ([Ca–Cv]/Ca) × blood flow rate; where Ca = concentration of the solute in the
arterial line and Cv = concentration of the solute in the venous line and blood flow rate (mL/min). …