10.7554/eLife.26014.001 Phenomics, which ideally involves in-depth phenotyping at the
whole-organism scale, may enhance our functional understanding of genetic variation. Here, …

It is well recognized that dynamic loading serves as an anabolic stimulus for bone while
static loading alone is either ignored or is catabolic. However, dynamic lower limb loading …

Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene
as the most important genetic susceptibility locus in Alzheimer’s disease (AD) after APOE. …

Bruck syndrome (BS) is a disorder characterized by joint flexion contractures and skeletal
dysplasia that shows strong clinical overlap with the brittle bone disease osteogenesis …

… (NO 3 ) 2 , 5 mM Hepes, pH 7.6) with a tracer dye (0.5 mg/mL, dextran conjugated with
tetramethylrhodamine, Molecular Probes, Carlsbad, California, USA) in a final volume of 5 μL and …

TDP-43 proteinopathy is strongly implicated in the pathogenesis of amyotrophic lateral sclerosis
and related neurodegenerative disorders. Whether TDP-43 neurotoxicity is caused by a …

Tau-mediated neurodegeneration in Alzheimer’s disease and tauopathies is generally
assumed to start in a normally developed brain. However, several lines of evidence suggest that …

… Canada and the United States were among the first host states to be sued by foreign investors,
under the investment provisions of NAFTA's Chapter 11. As a result of this, they realized …

… The abnormal trichome phenotype was attributed to the reduced Ca 2+ binding of GlcA in
the glycan moieties of AGPs. The reduced GlcA levels decreased the Ca 2+ levels necessary …

In dyadic research, the actor–partner interdependence model (APIM) is widely used to model
the effect of a predictor measured across dyad members on one’s own and one’s partner …