Free radicals act as secondary messengers, modulating a number of important biological
processes, including gene expression, ion mobilization in transport systems, protein …

Background In two of three phase 3 trials, pirfenidone, an oral antifibrotic therapy, reduced
disease progression, as measured by the decline in forced vital capacity (FVC) or vital …

Background: This guideline addresses the diagnosis of hypersensitivity pneumonitis (HP). It
represents a collaborative effort among the American Thoracic Society, Japanese …

There is evidence to suggest that the cellular components of homografts and bioprosthetic
xenografts may contribute to calcification or immunogenic reactions. A fourstep detergent and …

Over the past few years an increasing number of prospective controlled sarcoidosis treatment
trials have been completed. Unfortunately, these studies utilize different endpoints making …

Pirfenidone is an antifibrotic agent that has been evaluated in three multinational phase 3
trials in patients with idiopathic pulmonary fibrosis (IPF). We analysed pooled data from the …

In Amazonia, millions of hectares of forest have been converted to cattle pasture then abandoned.
On sites with histories of heavy use, forest recovery is slow. We compared the process …

Chagas' disease is a zoonosis caused by the parasite Trypanosoma cruzi, a haematic
protozoan, transmitted by insects from the Reduviidae family. This constitutes a relevant health …

Background In clinical trials of idiopathic pulmonary fibrosis, rates of all-cause mortality are
low. Thus prospective mortality trials are logistically very challenging, justifying the use of …

The purpose of this study was to evaluate specific effects of photodynamic inactivation (PDI)
using methylene blue as photosensitizer and low-power laser irradiation on the viability of …