The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

Transcription factors control cell-specific gene expression programs through interactions
with diverse coactivators and the transcription apparatus. Gene activation may involve DNA …

The Mediator complex allows communication between transcription factors and RNA
polymerase II (RNAPII). Cyclin-dependent kinase 8 (CDK8), the kinase found in some variants of …

Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded
with the Mediator complex, transcription factors and chromatin regulators, drive high …

Mutations in the RNA-binding protein FUS (fused in sarcoma)/TLS have been shown to cause
the neurodegenerative disease amyotrophic lateral sclerosis (ALS), but the normal role of …

… into the functional role of the CC domains of TMCC1. The … CC. The Phyre2 structural
prediction program also predicts a high similarity (98.5%) between the long CC and a rigid CC …

Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19.
Using CA, we now report a large-scale identification of Mediator kinase substrates in human …

Promoter-proximal pausing of RNA polymerase II (Pol II) is a major checkpoint in transcription.
An unbiased search for new human proteins that could regulate paused Pol II at the …

… Ebmeier et al. use targeted proteomics to identify distinct interactomes for fulllength
mammalian pol II CTD phosphorylated by TFIIH or P-TEFb. In vitro and cell-based assays uncover …

The 26-subunit, 1.2 MDa human Mediator complex is essential for expression of perhaps all
protein-coding genes. Activator binding triggers major structural shifts within Mediator, …