A novel Netrin-1–sensitive mechanism promotes local SNARE-mediated exocytosis during axon branching
CC Winkle, LM McClain, JG Valtschanoff… - Journal of Cell …, 2014 - rupress.org
… S4, C–E), we conclude that the CC domain and likely SNAP25 binding of TRIM9 are required
to constrain exocytosis and branching, whereas ligase activity is dispensable. Interestingly, …
to constrain exocytosis and branching, whereas ligase activity is dispensable. Interestingly, …
[PDF][PDF] The E3 ubiquitin ligase TRIM9 is a filopodia off switch required for netrin-dependent axon guidance
…, NP Boyer, CC Winkle, LM McClain, CC Hanlin… - Developmental cell, 2015 - cell.com
… A GST-tagged protein containing the BBoxCC-COS domains of TRIM9 (BBCCC) bound …
-BBCC and GST-CC, but not GSTBBox, indicating that the CC domain is the minimal binding re…
-BBCC and GST-CC, but not GSTBBox, indicating that the CC domain is the minimal binding re…
Beyond the cytoskeleton: the emerging role of organelles and membrane remodeling in the regulation of axon collateral branches
CC Winkle, KL Taylor, EW Dent, G Gallo… - Developmental …, 2016 - Wiley Online Library
The generation of axon collateral branches is a fundamental aspect of the development of
the nervous system and the response of axons to injury. Although much has been discovered …
the nervous system and the response of axons to injury. Although much has been discovered …
Trim9 deletion alters the morphogenesis of developing and adult-born hippocampal neurons and impairs spatial learning and memory
During hippocampal development, newly born neurons migrate to appropriate destinations,
extend axons, and ramify dendritic arbors to establish functional circuitry. These …
extend axons, and ramify dendritic arbors to establish functional circuitry. These …
TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching
M Plooster, S Menon, CC Winkle… - Molecular biology of …, 2017 - Am Soc Cell Biol
… Movie S2: The TRIM9 ligase domain, DCC-binding SPRY domain, and TRIM multimerization
CC motif are required to fully rescue netrin-dependent clustering of DCC. Inverted time-…
CC motif are required to fully rescue netrin-dependent clustering of DCC. Inverted time-…
Membrane trafficking in neuronal development: ins and outs of neural connectivity
CC Winkle, SL Gupton - International review of cell and molecular biology, 2016 - Elsevier
… Author links open overlay panel Cortney Chelise Winkle 1 , Stephanie L. Gupton 1 2 3 …
) and Cortney Winkle was supported by the National Institutes of Health (F31NS087837). …
) and Cortney Winkle was supported by the National Institutes of Health (F31NS087837). …
Utilizing combined methodologies to define the role of plasma membrane delivery during axon branching and neuronal morphogenesis
CC Winkle, CC Hanlin, SL Gupton - JoVE (Journal of Visualized …, 2016 - jove.com
During neural development, growing axons extend to multiple synaptic partners by elaborating
axonal branches. Axon branching is promoted by extracellular guidance cues like netrin-…
axonal branches. Axon branching is promoted by extracellular guidance cues like netrin-…
Layering in colloidal fluids near a smooth repulsive wall
DH Van Winkle, CA Murray - The Journal of chemical physics, 1988 - pubs.aip.org
… The colloid is confined between two glass windows in the center of a large -100 cc reservoir
… We have also used smaller cells with a - 2 cc reservoir in direct contact with exchange resin …
… We have also used smaller cells with a - 2 cc reservoir in direct contact with exchange resin …
Unraveling the transcriptional networks that drive oligodendrocyte fate specification in Sonic hedgehog-responsive neocortical progenitors
CC Winkler, LN Tran, EP Milan, F García-Moreno… - bioRxiv, 2020 - biorxiv.org
In the developing nervous system, progenitors first generate neurons before making
astrocytes and oligodendrocytes. We previously showed that increased Sonic hedgehog (Shh) …
astrocytes and oligodendrocytes. We previously showed that increased Sonic hedgehog (Shh) …
The Precipitin Reaction to Phosphatides of Tubercle and Leprosy Bacilli
GR Duncan, CCV Winkle, ES Mariette… - American Review of …, 1935 - atsjournals.org
The Research Committee of the National Tuberculosis Association assigned us the problem
of standardizing the four phosphatides prepared by RJ Anderson from the human, avian …
of standardizing the four phosphatides prepared by RJ Anderson from the human, avian …