In many sensory systems, stimulus sensitivity is dynamically modulated through mechanisms
of peripheral adaptation, efferent input, or hormonal action. In this way, responses to …

TAS1R- and TAS2R-type taste receptors are expressed in the gustatory system, where they
detect sweet- and bitter-tasting stimuli, respectively. These receptors are also expressed in …

The peripheral sensory organ of the gustatory system, the taste bud, contains a heterogeneous
collection of sensory cells. These taste cells can differ in the stimuli to which they respond …

The taste of sweeteners is hedonically pleasing, suggests high caloric value in food, and
contributes to increased intake. In recent years, many of the molecular mechanisms underlying …

Dysregulation of thyroid hormones triiodothyronine and thyroxine (T3/T4) can impact
metabolism, body composition, and development. Thus, it is critical to identify novel mechanisms …

Modulation of sensory function can help animals adjust to a changing external and internal
environment. Even so, mechanisms for modulating taste sensitivity are poorly understood. …

Insensitivity to the bitter-tasting compound 6-n-propylthiouracil (PROP) has been proposed
as a marker for individual differences in taste perception that influence food preference and …

It is well known that nutritional intake can vary substantially as a function of demographic
variables such as ethnicity and/or sex. Although a variety of factors are known to underlie the …

The gustatory system provides critical information about the quality and nutritional value of
food before it is ingested. Thus, physiological mechanisms that modulate taste function in the …

Type 2 diabetes mellitus (T2DM), which is characterized by insulin and glucose dysregulation,
is a major contributor to the development of cardiovascular disease, renal failure and …