User profiles for C. D. Heldermon
 | Coy Don Heldermonuniversity of Florida Verified email at medicine.ufl.edu Cited by 1317 |
Mucopolysaccharidosis III (Sanfilippo Syndrome)-disease presentation and experimental therapies.
JA Gilkes, CD Heldermon - Pediatric endocrinology reviews: PER, 2014 - europepmc.org
Sanfilippo Syndrome or Mucopolysaccharidosis Ill (MPS Ill) is a group of lysosomal storage
diseases resulting from a deficiency of one of four lysosomal enzymes: Type A-heparan N-…
diseases resulting from a deficiency of one of four lysosomal enzymes: Type A-heparan N-…
TRIM29 suppresses TWIST1 and invasive breast cancer behavior
…, S Hatakeyama, WS May, MP Kladde, CD Heldermon… - Cancer research, 2014 - AACR
TRIM29 (ATDC) exhibits a contextual function in cancer, but seems to exert a tumor-suppressor
role in breast cancer. Here, we show that TRIM29 is often silenced in primary breast …
role in breast cancer. Here, we show that TRIM29 is often silenced in primary breast …
[HTML][HTML] Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B
CD Heldermon, AK Hennig, KK Ohlemiller, JM Ogilvie… - PloS one, 2007 - journals.plos.org
… Mice were exposed to light flashes of 10 ms duration and an intensity of 76.2 cd*s/m 2 . …
allowed to adapt to light with an intensity of 72.7 cd/m 2 for 20 min. ERG measurements were …
allowed to adapt to light with an intensity of 72.7 cd/m 2 for 20 min. ERG measurements were …
[HTML][HTML] Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells
Carbonic anhydrase IX (CAIX) and XII (CAXII) are transmembrane proteins that are associated
with cancer progression. We have previously described the catalytic properties of CAIX in …
with cancer progression. We have previously described the catalytic properties of CAIX in …
[HTML][HTML] Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells
…, DW Siemann, L Wu, CD Heldermon… - The Journal of …, 2016 - Am Soc Clin Investig
Carcinoma cells can acquire increased motility and invasiveness through epithelial-to-mesenchymal
transition (EMT). However, the significance of EMT in cancer metastasis has been …
transition (EMT). However, the significance of EMT in cancer metastasis has been …
High resolution functional photoacoustic tomography of breast cancer
Purpose: To evaluate the feasibility of functional photoacoustic tomography (fPAT) for high
resolution detection and characterization of breast cancer and to demonstrate for the first time …
resolution detection and characterization of breast cancer and to demonstrate for the first time …
[HTML][HTML] Therapeutic efficacy of bone marrow transplant, intracranial AAV-mediated gene therapy, or both in the mouse model of MPS IIIB
CD Heldermon, KK Ohlemiller, ED Herzog, C Vogler… - Molecular Therapy, 2010 - cell.com
Sanfilippo syndrome type B (MPS IIIB) is a lysosomal storage disease resulting from a
deficiency of N-acetyl-glucosaminidase (NAGLU) activity. In an attempt to correct the disease in …
deficiency of N-acetyl-glucosaminidase (NAGLU) activity. In an attempt to correct the disease in …
[HTML][HTML] Preferred transduction with AAV8 and AAV9 via thalamic administration in the MPS IIIB model: A comparison of four rAAV serotypes
JA Gilkes, MD Bloom, CD Heldermon - Molecular genetics and metabolism …, 2016 - Elsevier
Sanfilippo syndrome type B (MPS IIIB) is a lysosomal storage disease caused by a deficiency
of N-acetyl-glucosaminidase (NAGLU) activity. Since early therapeutic intervention is likely …
of N-acetyl-glucosaminidase (NAGLU) activity. Since early therapeutic intervention is likely …
A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells
…, D Khokhar, A Wolff, L Ai, CD Heldermon… - Biochemical …, 2019 - portlandpress.com
The most aggressive and invasive tumor cells often reside in hypoxic microenvironments and
rely heavily on rapid anaerobic glycolysis for energy production. This switch from oxidative …
rely heavily on rapid anaerobic glycolysis for energy production. This switch from oxidative …
Mucopolysaccharidosis type IIIB: a current review and exploration of the AAV therapy landscape
…, VN Jensen, CD Heldermon - Neural Regeneration …, 2023 - journals.lww.com
Mucopolysaccharidoses type IIIB is a rare genetic disorder caused by mutations in the gene
that encodes for N-acetyl-alpha-glucosaminidase. This results in the aggregation of heparan …
that encodes for N-acetyl-alpha-glucosaminidase. This results in the aggregation of heparan …