Degradation of tropoelastin and skin elastin by neprilysin

ACM Huertas, CEH Schmelzer, C Luise, W Sippl… - Biochimie, 2018 - Elsevier
… Six peptides with Pro at P2 or P3′ (GVPGAIPG, GGPGFGPG, PVPGGLAG, LVPGGVAD,
VKPGKVPG and PGVGVLPG) present in the NEP digests of CE or AE were docked into the …

[HTML][HTML] Elastin is heterogeneously cross-linked

…, J Brinckmann, W Sippl, CEH Schmelzer - Journal of Biological …, 2018 - ASBMB
Elastin is an essential vertebrate protein responsible for the elasticity of force-bearing tissues
such as those of the lungs, blood vessels, and skin. One of the key features required for the …

Characterization of honeybee venom by MALDI-TOF and nanoESI-QqTOF mass spectrometry

J Matysiak, CEH Schmelzer, RHH Neubert… - … of Pharmaceutical and …, 2011 - Elsevier
The aim of the study was to comprehensively characterize different honeybee venom samples
applying two complementary mass spectrometry methods. 41 honeybee venom samples …

The action of neutrophil serine proteases on elastin and its precursor

…, L Debelle, AS Weiss, RHH Neubert, CEH Schmelzer - Biochimie, 2012 - Elsevier
This study aimed to investigate the degradation of the natural substrates tropoelastin and
elastin by the neutrophil-derived serine proteases human leukocyte elastase (HLE), proteinase …

MMP-14 degrades tropoelastin and elastin

N Miekus, C Luise, W Sippl, T Baczek, CEH Schmelzer… - Biochimie, 2019 - Elsevier
… Author links open overlay panel Natalia Miekus a b c , Chiara Luise a , Wolfgang Sippl a ,
Tomasz Baczek b , Christian EH Schmelzer a d , Andrea Heinz a e … Groth, CEH Schmelzer

Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid

SS Sivan, B Van El, Y Merkher, CEH Schmelzer… - … et Biophysica Acta (BBA …, 2012 - Elsevier
BACKGROUND: Aging and degeneration of human intervertebral disc (IVD) are associated
with biochemical changes, including racemization and glycation. These changes can only …

Fabrication of Insoluble Elastin by Enzyme‐Free Cross‐Linking

…, M Pietzsch, T Groth, CEH Schmelzer - Macromolecular …, 2023 - Wiley Online Library
Elastin is an essential extracellular matrix protein that enables tissues and organs such as
arteries, lungs, and skin, which undergo continuous deformation, to stretch and recoil. Here, …

Shotgun proteome analysis of honeybee venom using targeted enrichment strategies

J Matysiak, J Hajduk, Ł Pietrzak, CEH Schmelzer… - Toxicon, 2014 - Elsevier
The aim of this study was to explore the honeybee venom proteome applying a shotgun
proteomics approach using different enrichment strategies (combinatorial peptide ligand …

Investigating the Role of (2S,4R)-4-Hydroxyproline in Elastin Model Peptides

…, A Laurita, A Heinz, CEH Schmelzer… - …, 2013 - ACS Publications
Post-translational modifications play a key role in defining the biological functions of proteins.
Among them, the hydroxylation of proline producing the (2S,4R)-4-hydroxyproline (Hyp) is …

[HTML][HTML] Extracellular matrix stiffness and composition regulate the myofibroblast differentiation of vaginal fibroblasts

…, C van de Westerlo-van Rijt, CEH Schmelzer… - International Journal of …, 2020 - mdpi.com
Fibroblast to myofibroblast differentiation is a key feature of wound-healing in soft tissues,
including the vagina. Vaginal fibroblasts maintain the integrity of the vaginal wall tissues, …