User profiles for C. L. Araya
 | Carlos L. ArayaCEO, Jungla Inc. Verified email at jungla.bio Cited by 3595 |
High-resolution mapping of protein sequence-function relationships
We present a large-scale approach to investigate the functional consequences of sequence
variation in a protein. The approach entails the display of hundreds of thousands of protein …
variation in a protein. The approach entails the display of hundreds of thousands of protein …
[HTML][HTML] Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
CRISPR-Cas9 screens are powerful tools for high-throughput interrogation of genome function,
but can be confounded by nuclease-induced toxicity at both on- and off-target sites, likely …
but can be confounded by nuclease-induced toxicity at both on- and off-target sites, likely …
A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function
The ability of a protein to carry out a given function results from fundamental physicochemical
properties that include the protein’s structure, mechanism of action, and thermodynamic …
properties that include the protein’s structure, mechanism of action, and thermodynamic …
Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes
JD Buenrostro, CL Araya, LM Chircus, CJ Layton… - Nature …, 2014 - nature.com
RNA-protein interactions drive fundamental biological processes and are targets for
molecular engineering, yet quantitative and comprehensive understanding of the sequence …
molecular engineering, yet quantitative and comprehensive understanding of the sequence …
Deep mutational scanning: assessing protein function on a massive scale
Analysis of protein mutants is an effective means to understand their function. Protein display
is an approach that allows large numbers of mutants of a protein to be selected based on …
is an approach that allows large numbers of mutants of a protein to be selected based on …
[HTML][HTML] Comparative analysis of regulatory information and circuits across distant species
Despite the large evolutionary distances between metazoan species, they can show remarkable
commonalities in their biology, and this has helped to establish fly and worm as model …
commonalities in their biology, and this has helped to establish fly and worm as model …
Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans
Elucidating the consequences of genetic differences between humans is essential for
understanding phenotypic diversity and personalized medicine. Although variation in RNA levels, …
understanding phenotypic diversity and personalized medicine. Although variation in RNA levels, …
Sushi. R: flexible, quantitative and integrative genomic visualizations for publication-quality multi-panel figures
Motivation: Interpretation and communication of genomic data require flexible and quantitative
tools to analyze and visualize diverse data types, and yet, a comprehensive tool to display …
tools to analyze and visualize diverse data types, and yet, a comprehensive tool to display …
Enrich: software for analysis of protein function by enrichment and depletion of variants
Measuring the consequences of mutation in proteins is critical to understanding their function.
These measurements are essential in such applications as protein engineering, drug …
These measurements are essential in such applications as protein engineering, drug …
[HTML][HTML] Regulatory analysis of the C. elegans genome with spatiotemporal resolution
Discovering the structure and dynamics of transcriptional regulatory events in the genome
with cellular and temporal resolution is crucial to understanding the regulatory underpinnings …
with cellular and temporal resolution is crucial to understanding the regulatory underpinnings …