COVID-19–related genes in sputum cells in asthma. Relationship to demographic features and corticosteroids
…, P Deford, S Christenson, CL Rios… - American journal of …, 2020 - atsjournals.org
Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (…
coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (…
[HTML][HTML] Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium
…, MT Montgomery, JL Everman, CL Rios… - Nature …, 2020 - nature.com
Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that
utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting …
utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting …
[HTML][HTML] Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium
…, SP Sajuthi, N Dyjack, KS Li, CL Rios… - Nature …, 2020 - nature.com
Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium
and goes on to drive development of most chronic lung diseases. Here, through single cell …
and goes on to drive development of most chronic lung diseases. Here, through single cell …
Alternative splicing of interleukin-33 and type 2 inflammation in asthma
ED Gordon, LJ Simpson, CL Rios… - Proceedings of the …, 2016 - National Acad Sciences
Type 2 inflammation occurs in a large subgroup of asthmatics, and novel cytokine-directed
therapies are being developed to treat this population. In mouse models, interleukin-33 (IL-33…
therapies are being developed to treat this population. In mouse models, interleukin-33 (IL-33…
[PDF][PDF] Single-cell and population transcriptomics reveal pan-epithelial remodeling in type 2-high asthma
…, L Feriani, KC Goldfarbmuren, SP Sajuthi, CL Rios… - Cell reports, 2020 - cell.com
The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus
obstruction of the airways. To further investigate this incompletely understood pathobiology, we …
obstruction of the airways. To further investigate this incompletely understood pathobiology, we …
[HTML][HTML] Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium
…, ND Jackson, MT Montgomery, JL Everman, CL Rios… - Biorxiv, 2020 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID-19) outcomes vary from asymptomatic infection to death.
This disparity may reflect different airway levels of the SARS-CoV-2 receptor, ACE2, and the …
This disparity may reflect different airway levels of the SARS-CoV-2 receptor, ACE2, and the …
[HTML][HTML] Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology
…, JL Everman, ND Jackson, B Saef, CL Rios… - Nature …, 2022 - nature.com
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide
association study for asthma by combining RNA-seq data from the nasal airway epithelium of …
association study for asthma by combining RNA-seq data from the nasal airway epithelium of …
Management of emergency department patients with primary spontaneous pneumothorax: needle aspiration or tube thoracostomy?
S Zehtabchi, CL Rios - Annals of emergency medicine, 2008 - Elsevier
STUDY OBJECTIVE: The emergency management of primary spontaneous pneumothorax
is controversial. This evidence-based emergency medicine review evaluates the existing …
is controversial. This evidence-based emergency medicine review evaluates the existing …
Genome-Wide Analysis Reveals Mucociliary Remodeling of the Nasal Airway Epithelium Induced by Urban PM2.5
…, SP Sajuthi, SH Cho, JL Everman, CL Rios… - American journal of …, 2020 - atsjournals.org
Air pollution particulate matter <2.5 μm (PM 2.5 ) exposure is associated with poor
respiratory outcomes. Mechanisms underlying PM 2.5 -induced lung pathobiology are poorly …
respiratory outcomes. Mechanisms underlying PM 2.5 -induced lung pathobiology are poorly …
[HTML][HTML] IL1RL1 asthma risk variants regulate airway type 2 inflammation
…, A Wesolowska-Andersen, L Ringel, CL Rios… - JCI insight, 2016 - ncbi.nlm.nih.gov
Genome-wide association studies of asthma have identified genetic variants in the IL1RL1
gene, but the molecular mechanisms conferring risk are unknown. IL1RL1 encodes the ST2 …
gene, but the molecular mechanisms conferring risk are unknown. IL1RL1 encodes the ST2 …