Background and aims Enlarged perivascular spaces (also known as Virchow-Robin spaces)
on T2-weighted brain magnetic resonance imaging are common, but their etiology, and …

… Schnier C, Sudlow C. Definitions of acute myocardial infarction (MI) and main MI
pathological types for UK Biobank phase 1 outcomes adjudication: UK Biobank; 2017. https://biobank.…

Background and Purpose—On brain imaging, lacunes, or cerebrospinal fluid–containing
cavities, are common and are often counted in epidemiological studies as old lacunar infarcts. …

Background The most widely studied and prescribed antiplatelet agent for the prevention of
stroke and other serious vascular events among high vascular risk patients is aspirin. Aspirin …

Objective To systematically investigate causal relationships between obesity and cerebrovascular
disease and the extent to which hypertension and hyperglycemia mediate the effect of …

Rationale: Ischemic stroke is among the leading causes of adult disability. Part of the variability
in functional outcome after stroke has been attributed to genetic factors but no locus has …

Background and Objectives Anti-inflammatory therapies reduce major adverse cardiovascular
events (MACE) in coronary artery disease but remain unproven after stroke. Establishing …

Importance Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on
white participants, but genetic risk may vary or could be concealed by differing nongenetic …

Objective In observational epidemiologic studies, higher plasma high‐density lipoprotein
cholesterol (HDL‐C) has been associated with increased risk of intracerebral hemorrhage (ICH…

Background and Purpose— Atrial fibrillation (AF) is a leading cause of cardioembolic stroke,
but the relationship between AF and noncardioembolic stroke subtypes are unclear. …