User profiles for C. M. Nemec

Corey Nemec

10x Genomics
Verified email at 10xgenomics.com
Cited by 993

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

…, P Shah, JC Bell, D Jhutty, CM Nemec… - Nature …, 2019 - nature.com
Understanding complex tissues requires single-cell deconstruction of gene regulation with
precision and scale. Here, we assess the performance of a massively parallel droplet-based …

[HTML][HTML] Emerging views on the CTD code

…, JR Tietjen, CM Nemec… - Genetics research …, 2012 - hindawi.com
The C-terminal domain (CTD) of RNA polymerase II (Pol II) consists of conserved heptapeptide
repeats that function as a binding platform for different protein complexes involved in …

Pathway connectivity and signaling coordination in the yeast stress‐activated signaling network

D Chasman, YH Ho, DB Berry, CM Nemec… - Molecular systems …, 2014 - embopress.org
… Samples were first loaded onto a 10 cm, 75 μm id precolumn packed with 5 μm C18 … acid
in acetonitrile) and then separated across a 25 cm, 50 μm id analytical column packed with 5 …

[PDF][PDF] Integrated single-cell transcriptomics and chromatin accessibility analysis reveals regulators of mammary epithelial cell identity

…, G Gutierrez, P Sun, D Jhutty, GXY Zheng, CM Nemec… - Cell reports, 2020 - cell.com
The mammary epithelial cell (MEC) system is a bilayered ductal epithelium of luminal and
basal cells, maintained by a lineage of stem and progenitor populations. Here, we used …

[HTML][HTML] Sc-compReg enables the comparison of gene regulatory networks between conditions using single-cell data

…, P Shah, J Xin, F Meschi, ML Li, CM Nemec… - Nature …, 2021 - nature.com
The comparison of gene regulatory networks between diseased versus healthy individuals
or between two different treatments is an important scientific problem. Here, we propose sc-…

Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner

CM Nemec, F Yang, JM Gilmore… - Proceedings of the …, 2017 - National Acad Sciences
The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II)
orchestrates dynamic recruitment of specific cellular machines during different stages of …

Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner

CM Nemec, AK Singh, A Ali, SC Tseng, K Syal… - Nature chemical …, 2019 - nature.com
Phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase
II (Pol II) governs stage-specific interactions with different cellular machines. The CTD …

Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity

…, G Gutierrez, P Sun, D Jhutty, GXY Zheng, CM Nemec… - bioRxiv, 2019 - biorxiv.org
The mammary epithelial cell (MEC) system is a bi-layered ductal epithelial network consisting
of luminal and basal cells, which is maintained by a lineage of stem and progenitor cell …

[HTML][HTML] Numerical prediction of meteoric infrasound signatures

M Nemec, MJ Aftosmis, PG Brown - Planetary and Space Science, 2017 - Elsevier
We present a thorough validation of a computational approach to predict infrasonic signatures
of centimeter-sized meteoroids. This is the first direct comparison of computational results …

Diagnosing sarcopenia on thoracic computed tomography: quantitative assessment of skeletal muscle mass in patients undergoing transcatheter aortic valve …

U Nemec, B Heidinger, C Sokas, L Chu… - Academic radiology, 2017 - Elsevier
… Thoracic cutoff values for the 12th thoracic level were 42.6 cm 2 /m 2 (men) and 30.6 cm 2
/m 2 (women), and those for the 7th thoracic level were 46.5 cm 2 /m 2 (men) and 32.3 cm 2 /m …