… Levy at al. describe a highly multiplexed droplet digital PCR assay that simultaneously
quantifies likely intact HIV-1 proviruses and T lymphocytes. They validate the assay in cell and …

Background Hormonal changes during the menstrual cycle play a key role in shaping
immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, …

A major barrier to conducting HIV cure research in populations with the highest HIV burden
is the lack of an accurate assay to quantify the replication-competent reservoir across the …

A proposed strategy to cure HIV uses latency-reversing agents (LRAs) to reactivate latent
proviruses for purging HIV reservoirs. A variety of LRAs have been identified, but none has yet …

Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted
infections (STIs). It is unknown whether beginning to have sexual intercourse results in …

Objective: Prior genomewide association studies have identified variation in major
histocompatibility complex (MHC) class I alleles and C–C chemokine receptor type 5 gene (CCR5Δ32…

Background: medication-assisted treatment (MAT) with buprenorphine is now widely
prescribed to treat addiction to heroin and other illicit opioids. There is some evidence that illicit …

Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are used for HIV treatment and
prevention. Previously, we found that topical rectal tenofovir gel caused immunological …

The major barrier to an HIV cure is the HIV reservoir: latently-infected cells that persist
despite effective antiretroviral therapy (ART). There have been few cohort-based studies …

Background Cryopreservation of leukocytes isolated from the cervicovaginal and colorectal
mucosa is useful for the study of cellular immunity (see Hughes SM et al. PLOS ONE 2016). …