This review provides an outline for fluorescent labeling of proteins. Fluorescent assays are
very diverse providing the most sensitive and robust methods for observing biological …

Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion, links
the actin cytoskeleton to integrin-based cell–extracellular matrix adhesions at the plasma …

Unconventional myosins are multi-potent molecular motors that are assigned important roles
in fundamental cellular processes. Depending on their mechano-enzymatic properties and …

In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical properties
of the nucleus and its ability to sense external mechanical cues are tightly linked to the …

AntiJen is a database system focused on the integration of kinetic, thermodynamic, functional,
and cellular data within the context of immunology and vaccinology. Compared to its …

10.7554/eLife.06659.001 Smc–ScpAB forms elongated, annular structures that promote
chromosome segregation, presumably by compacting and resolving sister DNA molecules. The …

SMC condensin complexes are central modulators of chromosome superstructure in all
branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a …

Background pK a values are a measure of the protonation of ionizable groups in proteins.
Ionizable groups are involved in intra-protein, protein-solvent and protein-ligand interactions …

DNA double-strand breaks drive genomic instability. However, it remains unknown how these
processes may affect the biomechanical properties of the nucleus and what role nuclear …

Myosin VI (MVI) has been found to be overexpressed in ovarian, breast and prostate cancers.
Moreover, it has been shown to play a role in regulating cell proliferation and migration, …