Mycobacterium tuberculosis is a globally distributed, lethal pathogen of humans. The
virulence armamentarium of M. tuberculosis appears to have been developed on a scaffold of …

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium
tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely …

Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), is estimated to infect a
new host every second. While analyses of genetic data from natural populations of M.tb have …

A small number of high-burden countries account for the majority of tuberculosis cases
worldwide. Detailed data are lacking from these regions. To explore the evolutionary history of …

… We would like to thank past and present members of the Pepperell Laboratory for helpful
feedback on the project, and particularly highlight Trent Prall for his contribution to preliminary …

Severe outbreaks and deaths have been linked to the emergence and global spread of
fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, …

The “Beijing” Mycobacterium tuberculosis (Mtb) lineage 2 (L2) is spreading globally and has
been associated with accelerated disease progression and increased antibiotic resistance. …

Patterns of gene flow can have marked effects on the evolution of populations. To better
understand the migration dynamics of Mycobacterium tuberculosis, we studied genetic data from …

Evidence-based public health approaches that minimize the introduction and spread of new
SARS-CoV-2 transmission clusters are urgently needed in the United States and other …

Tuberculosis (TB) is a global public health emergency. Increasingly drug resistant strains of
Mycobacterium tuberculosis (M.tb) continue to emerge and spread, highlighting adaptability …