Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems 1 , 2 , 3 , 4 – 5 . Whether the neo-innervation of tumours by pain-…

Patients with densely innervated tumors suffer with increased metastasis and decreased
survival as compared to those with less innervated tumors. We hypothesize that in some tumors…

Objective Recently, our laboratory identified sensory innervation within head and neck
squamous cell carcinomas (HNSCCs) and subsequently defined a mechanism whereby …

Tumor cell metabolism differs from that of normal cells, conferring tumors with metabolic
advantages but affording opportunities for therapeutic intervention. Accordingly, metabolism-…

The incidence of human papillomavirus-associated head and neck squamous cell carcinoma
(HPV[ + ] HNSCC) is rapidly increasing. Although clinical management of primary HPV( + ) …

Standard-of-care cisplatin and radiation therapy (CRT) provides significant tumor control of
human papillomavirus (HPV)-mediated head and neck squamous cell carcinomas (HNSCCs)…

The molecular and functional contributions of intratumoral nerves to disease remain largely
unknown. We localized synaptic markers within tumors suggesting that these nerves form …

Patients with densely innervated tumors do poorly as compared to those with sparsely
innervated disease. Why some tumors heavily recruit nerves while others do not, remains …

Simple Summary Blockade of the PD-1/L1 interaction represents a breakthrough in the
treatment for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). Clinical …

Patients with densely innervated tumors do worse than those with less innervated cancers.
We hypothesize that neural elements are acquired by a tumor-induced process, called neo-…