Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that
encompasses Crohn’s disease (CD) and ulcerative colitis. The cause of IBD is unknown, but the …

Foxp3 + regulatory T (T reg) cells play a key role in controlling immune pathological re
actions. Many develop their regulatory activity in the thymus, but there is also evidence for …

Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was
introduced in the United Kingdom to accelerate population coverage with a single dose. At this …

Host microbial cross-talk is essential to maintain intestinal homeostasis. However, maladaptation
of this response through microbial dysbiosis or defective host defense toward invasive …

… Geremia and CV Arancibia-Cárcamo contributed equally to … Program of the Broad Foundation
(CV Arancibia-Cárcamo). … Geremia and CV Arancibia-Cárcamo contributed equally to …

Interleukin-23 (IL-23) is an inflammatory cytokine that plays a key role in the pathogenesis
of several autoimmune and inflammatory diseases. It orchestrates innate and T cell-mediated …

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of T cell
responses. Germline Ctla4 deficiency is lethal, making investigation of the function of CTLA-4 on …

MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent
and TCR-independent mechanisms. Here, we examined the impact of …

Identification of protective T cell responses against SARS-CoV-2 requires distinguishing
people infected with SARS-CoV-2 from those with cross-reactive immunity to other …